Chelsea virtually guaranteed their passage into the Champions League knockout phase with a hard-fought win.
John Terry set Jose Mourinho's side on the way to their third successive victory in the competition with a close-range header after nine minutes.
And Eidur Gudjohnsen headed a second on the stroke of half-time.
The result was harsh on CSKA, who were denied by Chelsea goalkeeper Petr Cech as he pulled off a succession of fine saves to keep the Russians at bay.
Chelsea, looking to bounce back from their first Premiership defeat of the season at Manchester City, were given the perfect start by inspirational captain Terry.
Damien Duff's corner was headed down by Gudjohnsen, and Terry was lurking to head home.
But CSKA had every right to feel aggrieved that they were behind as they dominated impressively for spells, only to be denied by the outstanding Cech.
He saved brilliantly from Sergei Ignashevich's long-range drive after an earlier fine stop from Daniel Carvalho.
Terry was Chelsea's main attacking threat, flashing a header narrowly wide before Cech came to Chelsea's rescue again four minutes before the interval.
Gudjohnsen deflected a corner towards his own goal from six yards, and the giant Cech responded in stunning fashion with a miraculous one-handed save.
The goalkeeper's efforts were shown to be even more important as Chelsea doubled their advantage on the stroke of half-time.
CSKA were undone again by their inability to defend set-pieces, Gudjohnsen arriving unmarked to power Duff's free-kick past Igor Akinfeev.
Cech was CSKA's tormentor again after 55 minutes, diving to his left to turn away Yevgeny Aldonin's shot from 25 yards.
Mateja Kezman had suffered another disappointing night up front for Chelsea, and it was no surprise when he was replaced by Tiago just after the hour.
It was a stop-start display from Chelsea, but there were few complaints from a satisfied Stamford Bridge crowd as they contemplated Champions League progress.
Chelsea: Cech, Bridge, Terry, Gallas, Paulo Ferreira, Lampard, Duff (Cole 76), Smertin (Parker 84), Makelele, Kezman (Tiago 62), Gudjohnsen. Subs Not Used: Cudicini, Johnson, Ricardo Carvalho, Geremi.
Goals: Terry 9, Gudjohnsen 45.
CSKA Moscow: Akinfeev, Semberas, Semak (Krasic 71), Berezoutski, Ignashevich, Carvalho (Laizans 24), Vagner Love (Dadu 60), Odiah, Zhirkov, Aldonin, Rahimic. Subs Not Used: Mandrykin, Ferreira, Kirichenko, Shershun.
Ref: Lubos Michel (Slovakia).