Lazio had to come from behind twice to snatch a 3-3 draw against Polish side Wisla Krakow on an humiliating night for the Italian giants.
Lazio were pushed all the way by their Polish opponents
Nikola Lazetic put Lazio in front but Kalu Uche levelled and then Maciej Zurawski put Krakow in front from the penalty spot.
A Mariusz Jop own goal let the Rome team back in but a second goal from Zurawski made it 3-2 to the Poles, only for Enrico Chiesa to grab a draw for Lazio 19 minutes from time.
By that time Lazio were delighted just to avoid defeat but they will be concerned that Krakow take three away goals back to Poland.
Liverpool grabbed a priceless away win at Auxerre thanks to an unlikely goal from centre-back Sami Hyypia.
The club captain finished with aplomb after collecting Danny Murphy's pass to ensure Liverpool take a vital victory back to England.
Celtic came from behind to beat 10-man VfB Stuttgart 3-1 in Glasgow.
Marcelo Bordon received his marching orders for the Germans in the first half but they shrugged that off to take the lead through Kevin Kuranyi.
But Celtic hit back through Paul Lambert, Shaun Maloney who was taking the place of Henrik Larsson and Stilian Petrov to carry a healthy advantage to Stuttgart for the second leg.
A spectacular goal from Dick van Burik three minutes into stoppage time earned Hertha Berlin a 3-2 win over Boavista in their fourth round first leg tie.
The Dutchman ensured his side will travel to Portugal with a lead intact after the visitors thought they had done enough for a draw.
Brazilian Alex Alves, who scored both goals in Hertha's 2-0 victory over Borussia Moenchengladbach on Sunday, grabbed another brace.
But each time he scored Boavista pegged back the Germans, through Rui Costa and then substitute Alexandre Goulart with 10 minutes remaining.
But Van Burick popped up with an overhead kick to win it.
Lazio 3-3 Wisla Krakow
Hertha Berlin 3-2 Boavista
Panathinaikos 3-0 Anderlecht
Slavia Prague 1-0 Besiktas
Celtic 3-1 VfB Stuttgart
Malaga 0-0 AEK Athens
Porto 6-1 Denizlispor
Panathinaikos took a giant stride towards the quarter-finals when they beat Anderlecht 3-0.
Nigerian-born Poland striker Emmanuel Olisadebe scored two and laid on a third for Nikos Liberopoulos in a one-sided match.
A second-half goal by striker Tomas Dosek gave Slavia Prague a 1-0 win over Besiktas in the Czech Republic.
Dosek collected a pass from Slavia captain Richard
Dostalek in the 62nd minute to consign the Turks to their first defeat in the competition this season.
Their evening was further dampened when defender Carlos Antonio Zago was sent off for a second bookable offence.
Malaga drew 0-0 with AEK Athens in Spain while Porto crushed Turkish outfit Denizlispor 6-1 in Portugal.
Porto hit five goals without reply through Nuno Capucho, Derlei Silva, Ricardo Costa, Edgaras Jankauskas and Deco Souza before Denizlispor pulled one back through Roman Kratochvil.
But Dimitri Alenitchev made it 6-1 for Porto.