Yakubu (right) celebrates with Anichebe (left) and Lescott
Everton sealed Uefa Cup football as defender Joleon Lescott continued his remarkable goalscoring season.
Lescott volleyed home his 10th goal in all competitions to set up a comfortable win over Newcastle.
Yakubu headed Everton into a first-half lead, which was cancelled out by Michael Owen's penalty.
After Lescott had restored Everton's lead, Yakubu sealed victory with his second goal, slotting home The Toffees' first penalty of the season.
Interview: Everton boss David Moyes
The end of the season arrived at the right time for two teams whose resources were stretched by injury.
Tony Hibbert and Andy Johnson became the latest additions to Everton's injury list, while Newcastle boss Kevin Keegan was forced to make four changes, with Geremi, Joey Barton, Mark Viduka and Obafemi Martins all absent.
In the opening minute, Jose Enrique's pass released Charles N'Zogbia, and Everton keeper Tim Howard needed Phil Jagielka's intervention after he failed to hold the Newcastle winger's cross.
Interview: Newcastle boss Kevin Keegan
Howard then had to drop sharply on to a snap shot from teenage striker Andy Carroll, looking to mark his first Premier League start with a goal.
Everton's first sniff came when Yakuku skipped a couple of token challenges from Nicky Butt and Damien Duff only to screw his shot wide.
There was certainly little danger of the pea in referee Peter Walton's whistle wearing out as the first half meandered along with little in the way of physicality.
N'Zogbia's cross from the left begged for a touch and Newcastle boss Keegan's frustration was increased when Everton took the lead.
Duff's foul on Leon Osman gave Manuel Fernandes the opportunity to whip in a ball which Yakubu powerfully headed home for his 14th Premier League goal of the season.
Yakubu gets in front of Steven Taylor to head Everton in front
N'Zogbia almost pulled Newcastle level when he dipped a free-kick just over, while at the other end, Steve Harper twice denied Victor Anichebe his first Premier League goal since the opening day, and Joseph Yobo contrived to head over from six yards.
Harper again stood between Everton and the cushion of a second, getting his angles right to deny Osman as Everton ended the first half strongly.
Newcastle shocked the home side by drawing level within a minute of the restart.
As the dangerous N'Zogbia made ground in the Everton box he was tripped by Yobo and although Owen's penalty was not convincing it crept under Tim Howard's dive as the England striker scored for the fourth successive game at Goodison Park.
Although a draw would be enough for Everton to clinch European football they went in search of a winner, but twice in the space of a minute, Harper produced top-drawer saves to keep out free-kicks from Fernandes.
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