With Manchester United still five points clear, and with a game in hand, Arsenal's title ambitions look all but over.
Wenger desperately needed a win here if his side were to retain any realistic hopes of overhauling United at the top but Liverpool were never likely to roll over.
As expected, both sides made several changes from the teams that drew 1-1 here on Wednesday in the first leg of their Champions League quarter-final.
Only three of the Liverpool side that started that match began here - goalkeeper Reina, Jamie Carragher and Martin Skrtel - as Reds boss Rafa Benitez confirmed his focus was on the second leg of that tie at Anfield on Tuesday.
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