Can Wenger's Arsenal keep their Premiership crown?
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The Premiership kicks off on Saturday with two new overseas bosses making their bow in English football.
Jacques Santini's Tottenham host Rafael Benitez's Liverpool, who will have to face up to life in the Premiership without star striker Michael Owen.
Defending champions Arsenal aim to make it 41 league games unbeaten on Sunday as Arsene Wenger's men take on Everton.
Also on Sunday, Chelsea's all-new star line-up under new coach Jose Mourinho against Manchester United.
Two of the Premiership new boys square up at Carrow Road on Saturday, as Division One champions Norwich host Iain Dowie's play-off winners Crystal Palace.
Saturday evening is likely to see the Premiership debut of Dutch striker Patrick Kluivert as his new club Newcastle make the short trip to to Teesside rivals Middlesbrough.
West Bromwich Albion return to the Premiership after an absence of one season with a trip to a Blackburn side many expect to struggle during this season.
Chelsea are not the only London team to have been active in the transfer market during the close season - and Charlton have a host of new faces in their team.
Danish international Dennis Rommedahl and England duo Danny Murphy and Francis Jeffers are all available for Alan Curbishley's men as they travel to Bolton.