Liverpool sank to their first defeat of 2004 as Helder Postiga scored his first Premiership goal for Spurs.
The Portuguese striker guided the ball home soon after the restart to give Spurs a two-goal cushion.
Spurs had taken the lead in the first-half through Robbie Keane, who powered a penalty home after the Irishman was fouled by Igor Biscan.
Harry Kewell's dynamic shot and run had pulled a goal back for Liverpool with 15 minutes remaining.
Before that Liverpool's best chance had fallen to Michael Owen, playing his 200th Premiership game, as he flashed a 20-yard
volley just wide after Emile Heskey nodded on a Paul Jones' clearance early in the game.
Owen set Liverpool on the attack again after 20 minutes with a neat turn inside Gary Doherty and Darren Anderton before feeding Kewell on the right, but Doherty recovered well to cut out the return pass.
With Frederic Kanoute away on international duty with Mali, Postiga was making the most of another opportunity to impress manager David Pleat.
The Portuguese striker cut inside Stephane Henchoz and hit a low drive which Jones blocked on his six-yard line.
25 mins: Keane puts Liverpool ahead with a penalty
53 mins: Postiga breaks his Premiership duck
75 mins: Kewell's opportunistic goal brings brief hope to Liverpool
Liverpool won their first corner after 21 minutes and Kewell's cross was
deflected off the head of Biscan before looping into the arms of Kasey Keller.
Biscan was soon in the thick of action again, but for all the wrong reasons as he gave away the penalty.
Keane wriggled his way into the penalty area and Biscan clipped the Spurs striker's heels.
The Republic of Ireland international picked himself and dusted himself down to drive the ball into the corner.
Liverpool rallied and won a free-kick after 34 minutes when Michael Brown fouled Kewell on the edge of the visitors' box.
The Australian curled the cross towards Heskey, but it was just too high for him to
get a header on target.
Liverpool were in the ascendancy, winning two corners on their right, but
Keller cleared the first and Steve Carr the second.
Spurs were forced to make a change at the interval as Stephane Dalmat picked up a
knock and was replaced by Johnnie Jackson.
The young midfielder did not take long to make his mark slipping an intelligent pass through to Postiga, who steered the ball past Jones.
On 75 minutes Kewell gave Liverpool a glimmer of hope with a superb individualistic goal, running with the ball, before guiding his shot past Keller.
Late in the game Owen claimed a penalty, arguing Doherty had handled the ball.
Tottenham: Keller, Carr, Doherty, Gardner, Taricco, Brown,
Anderton, Dalmat (Jackson 45), Davies, Postiga (Zamora 78),
Subs not used: Hirschfeld, Bunjevcevic, Kelly.
Liverpool: Jones, Henchoz, Hyypia, Biscan (Finnan 66),
Traore (Riise 61), Murphy, Hamann, Kewell, Cheyrou, Heskey,
Subs not used: Dudek, Le Tallec, Carragher.
Referee: U Rennie (S Yorkshire).