Stand-in striker Bilel Mohsni made it three goals in a week to help Southend United earn their first home win since October in style.
Usually a defender, Mohsni converted from Ryan Hall's cross before Hall smashed home number two.
And Hall then laid on Mohsni again and Southend were in dreamland as Craig Easton made it 4-0 before the break, converting Mohsni's deflected shot.
Macclesfield's Colin Daniel fired home a late consolation from 12 yards.
Southend United manager Paul Sturrock told BBC Essex: "I think there have been a lot of games that we could have won and should have won but made some dramatic mistakes that's cost us dear.
"I think tonight lady luck has shone on us with a couple of goals that we don't normally score.
"But, at the end of the day, it turned into an exceptional performance."
Live text and stats
Tuesday, 25 January 2011
Npower League Two
05 Coughlan (Phillips 66)
06 Bilel (Corr 59)
07 Grant (Sawyer 72)
07 Chalmers (Hamshaw 56)
09 Sinclair (Mukendi 68)
Ref: RussellAtt: 5,011
Attempts on target
Attempts off target
90:00+2:03 The referee brings the game to a close.
90:00+1:30 Vinny Mukendi takes a shot. Mark Phillips gets a block in.
90:00+0:48 Blair Sturrock delivers the ball, save by Jose Veiga.
90:00+0:22 Hamza Bencherif concedes a free kick for a foul on Chris Barker. Direct free kick taken by Rhys Evans.
87:34 The assistant referee signals for offside against Barry Corr. Jose Veiga takes the direct free kick.
87:28 The ball is delivered by Ryan Hall, Izak Reid makes a clearance.
86:36 Centre by Dan Gray.
84:33 Foul by Blair Sturrock on Tyrone Barnett, free kick awarded. Dan Gray restarts play with the free kick.
83:59 The offside flag is raised against Vinny Mukendi. Free kick taken by Rhys Evans.
83:44 Sean Clohessy produces a cross, save by Jose Veiga.
Correction - 81:57 Corner taken by Ryan Hall played to the near post, Tyrone Barnett manages to make a clearance.
81:57 Corner taken left-footed by Ryan Hall to the near post, clearance by Vinny Mukendi.
81:40 Tyrone Barnett takes a shot. Jose Veiga makes a save.
79:45 Centre by Sean Clohessy, save by Jose Veiga.
78:28 Assist on the goal came from Vinny Mukendi.
78:28 GOAL - Colin Daniel:Southend 4 - 1 Macclesfield Colin Daniel finds the back of the net with a goal from deep inside the penalty box to the bottom right corner of the goal.
Southend 4-1 Macclesfield.
74:48 The ball is delivered by Dan Gray, Vinny Mukendi takes a shot. Save made by Rhys Evans.
74:32 The ball is delivered by Izak Reid, Peter Gilbert manages to make a clearance.
71:35 The assistant referee flags for offside against Barry Corr. Jose Veiga takes the direct free kick.
71:35 Substitution Lee Sawyer comes on in place of Anthony Grant.
71:04 Vinny Mukendi crosses the ball, clearance by Mark Phillips.
70:49 The ball is swung over by Matthew Hamshaw, Mark Phillips makes a clearance.
68:51 Inswinging corner taken from the right by-line by Ryan Hall.
68:33 Ryan Hall takes a shot. Jose Veiga makes a save.
This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.