Dave Winfield's second-half goal ended Gillingham's five-game winning run as Wycombe stay in the promotion places.
It was a first half of few chances but both sides went close with headers - Adebayo Afinfenwa for Gillingham and Ben Strevens for the home side.
Wycombe's goal arrived in the 64th minute, as Matt Bloomfield's corner was headed onto the bar by Andy Sandell and Winfield put in the rebound.
The Chairboys created a club record, scoring in their 19th consecutive game.
Wycombe manager Gary Waddock told BBC Three Counties Radio: "It's been a hectic time what with the weather and the games that goes along with it, but it has been good from our side to be able to pick up some points.
"We have played two teams in the last couple of days that are in top form and I'm delighted we picked up two wins.
"We wanted to get it right at home, and the crowd today got right behind the players, and that makes a huge difference."
Gillingham manager Andy Hessenthaler told BBC Radio Kent: "We were a bit unfortunate near the end because we did pile the pressure on at the end but they're a good side.
"The only disappointing thing for us is that we work hard on set plays - for and against - and that's what's ended up costing us the three points from a corner.
"I thought we looked a little bit tired today. They've had the same amount of games as us as well but especially first half we didn't really get going. But I can't fault the boys' effort - I think we've had to really dig deep to turn things around and maybe it's one game too many for us. "
Live text and stats
Monday, 3 January 2011
Npower League Two
05 Winfield yellow card
23 Westwood (McCoy 56)
15 Lawrence yellow card
04 Weston (Rooney 74)
07 Maher (Bentley 60 yellow card)
32 Martin (Barcham 43)
Ref: CrossleyAtt: 4,617
Attempts on target
Attempts off target
90:00+3:45 The referee brings the game to a close.
90:00+2:56 Danny Spiller takes the inswinging corner, Scott Rendell manages to make a clearance.
90:00+1:24 The official flags Ben Strevens offside. Alan Julian restarts play with the free kick.
89:49 Stuart Lewis challenges John Nutter unfairly and gives away a free kick. Danny Spiller sends in a cross, Mark Bentley produces
a header from inside the six-yard box that clears the bar.
88:34 Matthew Lawrence fouled by Stuart Beavon, the ref awards a free kick. John Nutter restarts play with the free kick.
86:55 Adebayo Akinfenwa gives away a free kick for an unfair challenge on Stuart Lewis. Dave Winfield takes the free kick.
85:38 Foul by Leon Johnson on Adebayo Akinfenwa, free kick awarded. Danny Spiller restarts play with the free kick.
84:57 Marvin McCoy fouled by Cody McDonald, the ref awards a free kick. Free kick taken by Nikki Bull.
83:09 Free kick awarded for an unfair challenge on Adebayo Akinfenwa by Leon Johnson. Mark Bentley takes the free kick.
82:21 Dave Winfield gives away a free kick for an unfair challenge on Josh Gowling. Alan Julian restarts play with the free kick.
81:51 Corner taken by Matt Bloomfield from the right by-line played to the near post.
81:06 The offside flag is raised against Adebayo Akinfenwa. Dave Winfield takes the indirect free kick.
79:48 Outswinging corner taken left-footed by Danny Spiller.
76:34 Luke Rooney challenges Andy Sandell unfairly and gives away a free kick. Leon Johnson restarts play with the free kick.
75:50 Matt Bloomfield takes a short corner.
74:07 Outswinging corner taken from the right by-line by Danny Spiller.
73:38 Shot by Cody McDonald. Blocked by Andy Sandell.
73:10 Substitution (Gillingham) makes a substitution, with Luke Rooney coming on for Curtis Weston.
72:34 Corner taken by Matt Bloomfield from the right by-line to the near post, Headed effort from deep inside the area by Andy Sandell
misses to the left of the goal.
Correction - 71:07 The official flags Cody McDonald offside. Leon Johnson takes the free kick.
71:07 The referee blows for offside. Free kick taken by Nikki Bull.
69:42 Inswinging corner taken from the left by-line by Danny Spiller, save made by Nikki Bull.
65:16 Outswinging corner taken by Matthew Lawrence from the right by-line played to the near post, Stuart Beavon has an effort at
goal from outside the box which misses left.
63:05 Corner taken right-footed by Matt Bloomfield to the near post, the assist for the goal came from Ben Strevens.
63:05 GOAL - Dave Winfield:Wycombe 1 - 0 Gillingham Dave Winfield scores a headed goal from inside the penalty box. Wycombe 1-0 Gillingham.
61:57 Mark Bentley challenges Stuart Lewis unfairly and gives away a free kick. Free kick taken by Stuart Lewis.
61:57 Booking Mark Bentley is cautioned by the ref for unsporting behaviour.
59:02 Substitution Kevin Maher leaves the field to be replaced by Mark Bentley.
58:05 Curtis Weston fouled by Ben Strevens, the ref awards a free kick. Indirect free kick taken by Kevin Maher.
56:08 Foul by Cody McDonald on Dave Winfield, free kick awarded. Nikki Bull takes the free kick.
55:08 Free kick awarded for a foul by Stuart Beavon on Matthew Lawrence.
55:08 Substitution (Wycombe) makes a substitution, with Marvin McCoy coming on for Chris Westwood.
50:42 The official flags Stuart Lewis offside. Alan Julian restarts play with the free kick.
49:51 Shot by Cody McDonald from 18 yards. Save made by Nikki Bull.
48:43 Effort on goal by Adebayo Akinfenwa from just inside the penalty area goes over the target.
47:05 Outswinging corner taken right-footed by Matt Bloomfield.
46:07 Free kick awarded for an unfair challenge on Stuart Lewis by Danny Spiller. Free kick crossed right-footed by Andy Sandell,
Matthew Lawrence gets a block in.
45:01 The referee blows his whistle to start the second half.
45:00+2:12 The ref blows to end the first period.
45:00+0:28 Matthew Lawrence is penalised for handball and concedes a free kick. Direct free kick taken by Matt Bloomfield.
42:43 Joe Martin challenges Ben Strevens unfairly and gives away a free kick. Dave Winfield takes the indirect free kick.
42:43 Substitution Joe Martin goes off and Andy Barcham comes on.
41:24 Dave Winfield gives away a free kick for an unfair challenge on Curtis Weston. John Nutter crosses the ball in from the free
kick, Dave Winfield makes a clearance.
41:24 Booking Dave Winfield receives a caution for unsporting behaviour.
36:30 Shot by Kevin Betsy. Alan Julian makes a save.
35:24 Stuart Beavon challenges Curtis Weston unfairly and gives away a free kick. Alan Julian restarts play with the free kick.
31:54 Header by Ben Strevens from deep inside the penalty area misses to the left of the target.
30:55 The referee blows for offside against Stuart Beavon. Alan Julian takes the indirect free kick.
28:31 Danny Spiller gives away a free kick for an unfair challenge on Stuart Lewis. Stuart Lewis takes the free kick.
27:18 Kevin Betsy challenges Danny Spiller unfairly and gives away a free kick. The free kick is swung in left-footed by John Nutter.
25:12 Effort on goal by Stuart Beavon from just inside the box goes harmlessly over the target.
23:05 Foul by Stuart Beavon on Matthew Lawrence, free kick awarded. Alan Julian restarts play with the free kick.
22:20 Ben Strevens takes a shot. Save made by Alan Julian.
13:01 Curtis Weston concedes a free kick for a foul on Kevin Betsy. Free kick taken by Matt Bloomfield, Kevin Betsy produces a drilled
right-footed shot from deep inside the penalty box which goes wide of the right-hand upright.
13:01 Booking Matthew Lawrence booked for unsporting behaviour.
11:56 Free kick awarded for an unfair challenge on Cody McDonald by Leon Johnson. Barry Fuller restarts play with the free kick.
10:46 Danny Spiller concedes a free kick for a foul on Kevin Betsy. Matt Bloomfield takes the free kick.
8:56 Corner from the right by-line taken by Joe Martin, Headed effort from inside the area by Adebayo Akinfenwa misses to the left
of the goal.
6:23 Unfair challenge on Andy Sandell by Danny Spiller results in a free kick. Free kick crossed right-footed by Matt Bloomfield,
Alan Julian makes a save.
3:09 Joe Martin takes the inswinging corner, Stuart Lewis makes a clearance.
1:42 Free kick awarded for a foul by John Nutter on Stuart Beavon. Indirect free kick taken by Chris Westwood.
1:07 Effort from deep inside the area by Matthew Lawrence clears the bar.
0:00 The referee gets the match started.
Live text and data provided by The Press Association.
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