Wycombe striker Scott McGleish's goal was enough to beat bottom side Lincoln.
The Imps were reduced to 10 men when Oliver Ryan was sent off for a high late tackle on Will Antwi.
It took the Chairboys just 10 minutes to make the most of the extra man when McGleish met Gary Holt's through ball to slot home from six yards.
Wycombe dominated after the break but could not beat Imps keeper Ben Smith, with Sergio Torres crashing one shot wide and hitting the bar with another.
Wycombe: Fielding, Martin, Johnson, Antwi, Stockley, Bullock, Holt, Torres, Oakes (Boucaud 87), McGleish (Sutton 82), Bloomfield.
Subs Not Used: Douglas, Woodman, Reid.
Booked: Torres.
Goals: McGleish 39.
Lincoln City: Smith, Green, Moses, Hone (Bencherif 83), Croft, Frecklington, Kerr, Dodds (John-Lewis 69), Warlow (Hand 68), Wright, Ryan.
Subs Not Used: Marriott, Amoo.
Sent Off: Ryan (27).
Booked: Kerr.
Att: 4,297
Ref: Graham Salisbury (Lancashire).
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