Jermaine Easter was Wycombe's hero for the second time in a week as his side won to strengthen their play-off hopes.
The striker side-footed home from Kevin Betsy's cross on 88 minutes to seal it, days after he had earned the Chairboys a Carling Cup draw against Chelsea.
Neither side had mustered a single effort on target until that, but the result was a little harsh on Chester.
Laurence Wilson twice shot wide for the hosts, while Jon Walters spurned a fine chance just before Easter's winner.
Chester: Danby, Artell, Westwood (Linwood 38), Bolland, Marples, Martinez, Hand, Bennett (Sandwith 58), Wilson, Blundell (Steele 58), Walters.
Subs Not Used: Palethorpe, Hessey.
Booked: Hand, Linwood, Martinez.
Wycombe: Batista, Martin, Williamson, O'Halloran, Golbourne, Grant, Oakes (Torres 46), Doherty (Anya 46), Palmer (Onibuje 74), Easter, Betsy.
Subs Not Used: Young, Crooks.
Goals: Easter 88.
Ref: N Swarbrick (Lancashire).