Izale McLeod scored twice as MK Dons won the first ever Buckinghamshire derby against 10-man Wycombe.
Keith Andrews opened scoring for the Dons in the 17th minute and McLeod added a second from the penalty spot after Mike Williamson's foul.
Tommy Mooney fired home from 10 yards to give Wycombe some hope.
But Tommy Doherty was sent off for a second bookable offence in the 80th minute and McLeod sealed the win with an exquisite 25-yard curler.
Milton Keynes Dons: Harper, Lewington, Diallo, Edds, Butler, McGovern, Andrews, Dyer, Wilbraham, Platt (Taylor 60), McLeod (Mitchell 90), Taylor (Gary Smith 89).
Subs Not Used: Baines, Crooks.
Booked: Diallo, Platt.
Goals: Andrews 17, McLeod 25 pen, 87.
Wycombe: Young, Stockley (Martin 73), O'Halloran, Antwi, Williamson, Betsy, Grant (Anya 46), Doherty, Bloomfield (Oakes 10), Mooney, Easter.
Subs Not Used: Palmer, Stonebridge.
Sent Off: Doherty (80).
Booked: Mooney, Oakes, Grant, Doherty, Stockley, Betsy.
Goals: Mooney 31.
Ref: R Beeby (Northamptonshire).