Jon Daly hit a hat-trick as Hartlepool secured their third successive victory.
Daly's first was a smart header from John Brackstone's corner and the second a thumping close-range finish from Willie Boland's low left-wing cross.
The striker missed out on a hat-trick on 35 minutes when he failed to connect after Matty Robson's perfect set up.
But he made no mistake on 68 minutes when his looping header from Brackstone's left-wing free-kick went in off the inside of the post.
Hartlepool: Konstantopoulos, Darren Williams, Nelson, Clark, Brackstone, Gibb, Boland, Liddle (Bullock 30), Robson, Porter (Brown 84), Daly (Eifion Williams 73).
Subs Not Used: Provett, Strachan.
Goals: Daly 20, 22, 68.
Wrexham: Ingham, Spender (Mike Williams 45), Steve Evans, Danny Williams, Valentine, Roche, Mark Jones, Crowell, Done (Newby 73), Llewellyn, McAliskey.
Subs Not Used: Michael Jones, Johnson, Marc Williams.
Booked: Steve Evans, Ingham.
Ref: G Sutton (Lincolnshire).