Nathan Tyson notched another double as Wycombe strolled to a comfortable win.
Tyson got the fourth - his 13th of the season - nine minutes from time after opening the scoring on 16 minutes.
Kevin Betsy doubled the lead six minutes later before Mark Jones' 54th minute effort gave the injury-hit visitors some hope of a comeback.
But Wycombe, the only unbeaten side in the league, were always in control and veteran Tommy Mooney soon restored the advantage before Tyson struck late on.
Wycombe: Talia, Senda, Johnson, Williamson, Easton, Torres (Burnell 73), Bloomfield, Oakes, Betsy, Mooney (Dixon 87), Tyson (Stonebridge 90).
Subs Not Used: Williams, Martin.
Goals: Tyson 16, Betsy 22, Mooney 58, Tyson 81.
Wrexham: Michael Jones, Bayliss, Danny Williams, Lawrence, Smith, Foy, Ferguson, Linwood (Mike Williams 45), Mark Jones, Walters (Reed 79), Bennett.
Subs Not Used: Mackin, Spender, Done.
Goals: Mark Jones 54.
Ref: G Lewis (Cambridgeshire).