Shrewsbury Town have been relegated from Division Three after being beaten by fellow strugglers Carlisle.
The defeat ends Shrewsbury's 53-year stay in the Football League.
They failed to register the win they needed to stand a chance of avoiding the drop down into the Conference.
Carlisle ensured their survival in the league and made sure the final relegation place will be fought over between Swansea City and Exeter City on Saturday.
More than 7,000 fans packed into Gay Meadow for the crucial game, including hundreds of supporters from Cumbria.
Shrewsbury took a deserved lead through a Nigel Jemson penalty after 31 minutes when Paul Raven fouled Luke Rodgers.
But their advantage lasted just five minutes as Brian Wake equalised for the visitors.
The home side then paid the price for poor defending as Wake completed a hat-trick which secured Carlisle's Third Division status heading into the final game of the season.
Ryan Lowe did not help Shrewsbury's cause when he was sent-off after 70 minutes for violent conduct.
Rodgers scored with a dipping shot for Shrewsbury with six minutes left but the two goals they needed to take their survival fight into the final game did not materialise.
Towards the end of the game Shrews fans called for the head of manager Kevin Ratcliffe, the former Everton and Wales defender.
Ratcliffe left the ground telling reporters: "The future can be sorted out tomorrow."
He told one angry supporter: "I have a wife and kids at home and they deserve to know what I'm about to do before any of you."
Shrewsbury: Cartwright, Thompson, Wilding, Murray, Holt, Aiston, Glenn Tolley, Hulbert, Woan, Rodgers, Jemson. Subs:
Artell, Moss, Lowe, Watts, Jagielka.
Carlisle: Glennon, Birch, Murphy, Raven, Maddison, Baldacchino, Summerbell, McCarthy, Russell, Foran, Wake. Subs: Shelley, Keen, McGill, Andrews, Farrell.
Referee: B Curson (Leicestershire)