Dean Hammond scored against his former side and helped Southampton to a win against 10-man Colchester.
A deflected Rickie Lambert free-kick fell to Alex Oxlade-Chamberlain, who struck from close range to put the visitors ahead.
The home side were reduced to 10 men when David Mooney was dismissed for pushing Danny Butterfield.
Hammond fired in a low effort from the edge of the area to double the Saints' lead and seal the points.
Colchester United manager John Ward told BBC Essex: "It was a good game, 11 against 11. I thought we had given as good as we got.
"We restricted them to the opportunities they got. They got a break off the free-kick, but we always knew Lambert was dangerous, but we dealt with that and it dropped for them.
"The sending off changes the whole nature of the afternoon for everybody, not just the players but the supporters as well."
Southampton manager Nigel Adkins told BBC Radio Solent: You've got to come away from home and weather the storm.
"Great discipline from the players especially Lee Barnard who kept getting booted. He didn't retaliate which is what we talked about at half-time.
"The players bounced back after the disappointment the other day, kept a good clean sheet and got a good valuable three points."
Live text and stats
Saturday, 5 March 2011
Npower League One
06 N Clarke yellow card
10 Izzet (Bond 64)
22 Wordsworth (Gillespie 63)
15 Odejayi (Vincent 80)
19 Mooney red card
15 Jaidi (Martin 70)
26 Oxlade-Chamberlain (Richardson 87)
09 Barnard yellow card (N'Guessan 79)
Ref: Phil GibbsAtt: 6,523
Attempts on target
Attempts off target
90:00+5:30 The game is over, as the referee blows his whistle.
90:00+4:41 Free kick awarded for an unfair challenge on Steven Gillespie by Aaron Martin. Lloyd James takes the free kick.
90:00+4:12 The referee blows for offside against Dany N'Guessan. Free kick taken by Ben Williams.
90:00+2:50 Nathan Clarke challenges Richard Chaplow unfairly and gives away a free kick. Kelvin Davis takes the direct free kick.
86:51 Substitution Alex Oxlade-Chamberlain goes off and Frazer Richardson comes on.
86:12 Corner taken right-footed by Lloyd James.
85:26 Inswinging corner taken by Adam Lallana, save by Ben Williams.
83:20 Adam Lallana takes a shot. Save made by Ben Williams. Corner taken right-footed by Alex Oxlade-Chamberlain, save made by Ben
80:41 Corner from the right by-line taken by Lloyd James, Dany N'Guessan manages to make a clearance.
79:53 Substitution Ashley Vincent is brought on as a substitute for Kayode Odejayi.
78:03 Lee Barnard produces a left-footed shot from deep inside the penalty box which goes wide of the left-hand post.
78:03 Substitution (Southampton) makes a substitution, with Dany N'Guessan coming on for Lee Barnard.
77:02 Ben Coker is ruled offside. Kelvin Davis takes the indirect free kick.
73:46 Lloyd James takes the inswinging corner, clearance by Richard Lambert.
71:13 The referee blows for offside. Kelvin Davis takes the free kick.
70:00 Corner taken right-footed by Lloyd James from the left by-line, Headed effort from deep inside the penalty area by Nathan
Clarke goes harmlessly over the crossbar.
70:00 Substitution Radhi Jaidi goes off and Aaron Martin comes on.
68:13 Corner taken right-footed by Lloyd James from the left by-line to the near post, Richard Lambert manages to make a clearance.
66:18 Alex Oxlade-Chamberlain is ruled offside. Ben Williams takes the indirect free kick.
Correction - 63:00 Substitution Kemal Izzet leaves the field to be replaced by Andy Bond.
Correction - 63:00 Substitution Anthony Wordsworth goes off and Steven Gillespie comes on.
63:00 Substitution (Colchester) makes a substitution, with Andy Bond coming on for Kemal Izzet.
63:00 Substitution Steven Gillespie joins the action as a substitute, replacing Anthony Wordsworth.
61:03 Nathan Clarke challenges Lee Barnard unfairly and gives away a free kick. Jose Fonte takes the direct free kick.
58:42 Adam Lallana challenges John White unfairly and gives away a free kick. Lloyd James restarts play with the free kick.
57:57 Outswinging corner taken right-footed by Lloyd James from the right by-line, Jose Fonte manages to make a clearance.
56:57 Inswinging corner taken by Lloyd James from the left by-line, Anthony Wordsworth produces a header from inside the area that
goes over the bar.
56:35 Lloyd James decides to take the corner short.
53:09 Corner taken right-footed by Alex Oxlade-Chamberlain, save by Ben Williams. Richard Chaplow has an effort at goal from just
inside the box that misses to the right of the target.
51:09 Corner taken right-footed by Alex Oxlade-Chamberlain.
49:27 GOAL - Dean Hammond:Colchester 0 - 2 Southampton A goal is scored by Dean Hammond from inside the penalty area to the bottom left corner of the goal. Colchester 0-2 Southampton.
48:57 Alex Oxlade-Chamberlain decides to take a short corner.
46:45 Free kick awarded for an unfair challenge on Lloyd James by Lee Barnard. Matt Heath restarts play with the free kick.
45:13 The offside flag is raised against Anthony Wordsworth. Kelvin Davis takes the free kick.
45:01 The referee starts the second half.
45:00+8:55 The ref blows to signal half-time.
45:00+2:18 Ian Henderson takes a shot. Kelvin Davis makes a save.
45:00+1:36 Lloyd James produces a right-footed shot from just outside the area that goes wide left of the goal.
43:43 Richard Lambert takes a shot. Blocked by Matt Heath. Outswinging corner taken from the right by-line by Alex Oxlade-Chamberlain,
Ben Williams makes a save.
41:56 Shot from deep inside the area by Richard Lambert clears the crossbar.
39:19 Kayode Odejayi challenges Danny Butterfield unfairly and gives away a free kick. Free kick taken by Jose Fonte.
34:08 Corner taken by Lloyd James, save made by Kelvin Davis.
33:38 Corner taken by Alex Oxlade-Chamberlain from the right by-line, save by Ben Williams.
31:25 Sent off Red card for David Mooney.
29:45 Free kick awarded for an unfair challenge on Lee Barnard by Nathan Clarke. Strike comes in from Richard Lambert from the free
kick, blocked by Matt Heath. Richard Lambert provided the assist for the goal.
29:45 GOAL - Alex Oxlade-Chamberlain:Colchester 0 - 1 Southampton Alex Oxlade-Chamberlain gets on the score sheet with a goal from close range to the bottom left corner of the goal. Colchester
28:46 Booking Caution for Nathan Clarke.
26:16 Free kick awarded for a foul by Dean Hammond on Kemal Izzet. Free kick crossed right-footed by Lloyd James from left channel.
25:27 Richard Lambert has an effort at goal from the edge of the box that misses to the right of the target.
23:17 Outswinging corner taken by Alex Oxlade-Chamberlain, clearance by Kayode Odejayi.
21:56 Nathan Clarke concedes a free kick for a foul on Lee Barnard. Free kick taken by Richard Lambert.
21:21 Kayode Odejayi gives away a free kick for an unfair challenge on Jose Fonte. Direct free kick taken by Kelvin Davis.
19:53 The referee blows for offside against Ben Coker. Indirect free kick taken by Kelvin Davis.
17:53 Free kick awarded for an unfair challenge on Matt Heath by Lee Barnard. Ben Williams restarts play with the free kick.
17:53 Booking Lee Barnard receives a yellow card for unsporting behaviour.
15:09 The offside flag is raised against Anthony Wordsworth. Kelvin Davis takes the free kick.
14:19 Anthony Wordsworth takes a shot. Save made by Kelvin Davis.
13:22 Ian Henderson produces a right-footed shot from deep inside the penalty box which goes wide of the right-hand upright.
10:38 Dean Hammond concedes a free kick for a foul on Ian Henderson. The ball is delivered by Anthony Wordsworth, Lloyd James takes
a shot. Blocked by Richard Chaplow. Inswinging corner taken by Anthony Wordsworth, Radhi Jaidi makes a clearance.
7:55 Alex Oxlade-Chamberlain is penalised for handball and concedes a free kick. The free kick is swung in right-footed by Lloyd
James, Kelvin Davis makes a save.
6:18 Lloyd James has an effort at goal from outside the box which goes wide left of the goal.
5:42 The referee blows for offside against Richard Lambert. John White takes the free kick.
Correction - 3:38 David Mooney takes a shot. Save by Kelvin Davis.
3:38 David Mooney takes a shot. Save by Ben Williams.
0:00 The game gets underway.
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