Scunthorpe earned their ninth win in 10 League games to go top of the League One table on goal difference.
Martyn Woolford hit the opener from close range after Gary Hooper's pass before Tom Hope was denied an equaliser when Joe Murphy saved his header.
Hooper and Woolford both hit the woodwork after the break before Hooper set up Paul Hayes for the second.
Hayes had another effort disallowed for offside before Izzy Iriekpen headed the third from Woolford's corner.
Scunthorpe: Murphy, Byrne, Iriekpen, Mirfin, Williams, Sparrow, Togwell (Wright 89), Morris (Forte 85), Woolford, Hayes (May 84), Hooper. Subs Not Used: Lillis, Crosby.
Booked: Mirfin.
Goals: Woolford 35, Hayes 67, Iriekpen 80.
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Booked: Schumacher.
Att: 4,790
Ref: Clive Oliver (Northumberland).
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