Bristol City continued their push for promotion as Blackpool's play-off hopes took a severe knock at Bloomfield Road.
Wayne Andrews scored the only goal of the game early in the second half, breaking away from the hosts' defence and slotting home from a tight angle.
Keigan Parker hit a post for Blackpool in the first period but was then guilty of squandering a series of chances.
And when the Seasiders did get shots on target they found City's Brazilian goalkeeper Adriano Basso in great form.
Blackpool: Evans, Barker, Jackson, Evatt, Tierney (Jorgensen 79), Forbes (Burgess 69), Fox (Gillett 67), Southern, Hoolahan, Vernon, Parker.
Subs Not Used: Rachubka, Gorkss.
Bristol City: Basso, Fontaine, McCombe (Woodman 54), Keogh, Betsy, Noble, Johnson (Orr 46), Russell (Murray 28), Brian Wilson, Andrews, Brooker.
Subs Not Used: Weale, Jevons.
Booked: Fontaine, Murray.
Goals: Andrews 53.
Ref: C Oliver (Northumberland).