Eoin Jess scored his first goal of the season to salvage a draw for Northampton - although the hosts deserved to take all three points.
Blackpool scored against the run of play when Andy Morrell finished after Keigan Parker's pass on 20 minutes.
Northampton improved after the break and Jess equalised on 62 minutes with a superb curling shot into the corner.
The hosts almost claimed a winner when Scott McGleish rattled the crossbar and substitute Andy Kirk fired inches wide.
Northampton: Bunn, Bojic, Chambers, Doig, Crowe, Jess, Hunt (Cole 89), Taylor (Watt 46), McGleish, Burnell, Quinn (Kirk 46).
Subs Not Used: Dunn, Dyche.
Goals: Jess 62.
Blackpool: Evans, Barker, Jackson, Evatt, Dickinson, Forbes (Gillett 65), Southern, Fox, Hoolahan, Morrell (Burgess 75), Parker.
Subs Not Used: Vernon, Joseph, Jorgensen.
Booked: Hoolahan, Fox.
Goals: Morrell 20.
Ref: K Hill (Hertfordshire).