Carlisle secured a flattering win to climb up to fourth even though Blackpool dominated for long spells.
The Cumbrians took the lead in the 18th minute with Chris Lumsdon tapping in Karl Hawley's fierce cross-shot.
Blackpool sub Keigan Parker almost made his first touch count, but keeper Keiren Westwood made a fine save.
Hawley sealed victory for the Cumbrians two minutes from the end when he ran through and chipped visiting keeper Rhys Evans from just inside the box.
Carlisle: Westwood, Arnison, Gray, Murphy, Aranalde, Billy, Lumsdon, Thirlwell, Gall, Hawley, Hackney.
Subs Not Used: Williams, Livesey, Holmes, McDermott, Hindmarch.
Goals: Lumsdon 18, Hawley 88.
Blackpool: Evans, Barker, Evatt, Jackson, Coid, Gillett, Fox (Parker 81), Southern, Hoolahan, Burgess, Vernon (Morrell 73).
Subs Not Used: Jones, Prendergast, Joseph.
Ref: E Ilderton (Tyne & Wear).