Blackpool picked up their first points of the season with a comprehensive win.
Scott Vernon fired the visitors ahead only for Enoch Showunmi to fire an equaliser shortly before the interval.
Skipper Michael Jackson volleyed Blackpool back in front soon after the restart, but City hit back again through a Showunmi penalty.
Blackpool substitute Keigan Parker restored the visitors' lead with 13 minutes remaining and then made another for fellow substitute Danny Graham.
Bristol City: Basso, Orr (Keogh 68), Carey, Fontaine, Woodman, Johnson, Skuse (Cotterill 45), Noble, Jevons (Williams 61), Brooker, Showunmi.
Subs Not Used: Ballard, Russell.
Goals: Showunmi 43, 64 pen.
Blackpool: Evans, Barker, Jackson, Evatt, Forbes (Parker 51), Fox, Southern, Gillett, Vernon, Morrell (Graham 85), Paul Tierney (Joseph 83).
Subs Not Used: Edge, Hoolahan.
Goals: Vernon 27, Jackson 50, Parker 77, Graham 89.
Ref: M Russell (Hertfordshire).