Simon Grayson's debut as temporary boss of Blackpool ended in a thrilling win.
Billy Sharp's left-foot strike put the visitors ahead but John Murphy levelled and then Scunthorpe's Andy Crosby saw red for bringing down Tommy Wright.
Scunthorpe took a surprise lead when Sharp converted a penalty for Robert Edwards' foul on Andy Butler.
But the hosts led at half-time through Ian Morris' header and a crisp Tommy Wright strike before late goals from Murphy and Morris sealed it.
Blackpool: Pogliacomi, Warrender, Clarke, Edwards, Armstrong, Wiles (Prendergast 83), Southern, Doolan (Kay 90), Morris, Murphy, Wright (Vernon 74).
Subs Not Used: Jones, McGregor.
Booked: Doolan, Clarke, Wright, Morris.
Goals: Murphy 18, Morris 42, Wright 45, Murphy 84, Morris 90.
Scunthorpe: Musselwhite, Byrne, Crosby, Butler, Williams, Sparrow, Hinds, Baraclough, Corden (Taylor 74), Sharp, Keogh.
Subs Not Used: Stanton, Johnson, Ryan, Evans.
Sent Off: Crosby (20).
Goals: Sharp 3, 35 pen.
Att: 6,016
Ref: M Jones (Cheshire).