Argentine striker Pablo Bastianini's second-half header gave Yeovil their first win of the season.
Hartlepool dominated the first half but Michael Proctor, Ben Clark, Carl Jones and Adam Boyd all failed to make the most of some good openings.
Luciano Alvarez and Terry Skiverton sent headers wide for the Glovers after the break while Richie Humphreys had a goal disallowed for pushing.
But Yeovil won it when Bastianini headed in Lee Johnson's free-kick.
Hartlepool: Konstantopoulos, Darren Williams, Nelson, Jones, Robson, Humphreys, Sweeney, Clark, Butler (Bullock 50), Proctor, Boyd (Eifion Williams 32), Eifion Williams (Daly 64).
Subs Not Used: Tinkler, Provett.
Yeovil: Weale, Amankwaah, Skiverton, Fontaine, Miles, Gall, Way, Johnson, Jones, Alvarez (Terry 70), Bastianini (Harrold 82).
Subs Not Used: Lockwood, Collis, Poole.
Booked: Alvarez, Bastianini.
Goals: Bastianini 68.
Ref: D Drysdale (Lincolnshire).