Alex Rhodes and Deon Burton scored late in the second half as 10-man Brentford recovered to beat Sheffield Wednesday.
Michael Turner saw red in the 20th minute when he brought down Wednesday's Steven MacLean, who converted the subsequent penalty.
But the Bees upped their game after the break and took two minutes to turn the game in their favour.
On 80 minutes, Rhodes tapped in a John Salako corner before Burton grabbed the winner after help from Rhodes.
Sheff Wed: Lucas, Bullen, Heckingbottom, Branston (Talbot 84), Collins, Whelan, McGovern, Brunt, O'Brien, MacLean, Peacock (Hamshaw 66).
Subs Not Used: Poulter, Wood, Greenwood.
Booked: Peacock, Bullen.
Goals: MacLean 22 pen.
Brentford: Nelson, Turner, Frampton (Myers 45), Sodje, Talbot, Tabb, Hargreaves (Rankin 62), O'Connor, Salako, Burton, May (Rhodes 21).
Subs Not Used: Julian, Harrold.
Sent Off: Turner (20).
Goals: Rhodes 81, Burton 82.
Ref: M Cowburn (Lancashire).