Sheffield Wednesday gained revenge for four defeats by Blackpool in the League and Cup last season with victory.
Just before half-time, Chris Marsden set up Lee Bullen, who opened the scoring from 15 yards.
Blackpool equalised on 55 minutes when Marsden fouled Martin Bullock and Rob Edwards curled in a superb free-kick.
The Owls grabbed the winner with 10 minutes left when Lewis McMahon evaded the offside trap and beat Sasa Ilic from 20 yards.
Blackpool: Ilic, McGregor, Flynn, Clare, Richardson,
Parker (Barrowman 62), Robert Edwards, Wellens, Bullock,
Subs Not Used: Jones, Evans, Grayson, Doughty.
Goals: Robert Edwards 74.
Sheff Wed: Lucas, Collins, Lee, Branston, Bullen, McGovern,
Marsden, McMahon, Smith (Brunt 80), MacLean, Peacock,
Brunt (Shaw 90).
Subs Not Used: Tidman, Ndumbu-Nsungu, Carr.
Booked: Bullen, MacLean.
Goals: Bullen 44, McMahon 80.
Ref: A Marriner (W Midlands).