Jeremie Aliadiere scored a second-half double as Middlesbrough climbed into second spot and left struggling Ipswich still searching for a first league win.
Gary O'Neil headed in a Marvin Emnes cross to put Boro ahead.
Substitute Aliadiere doubled the lead with a neat close-range header after fine wingplay from Adam Johnson.
Aliadiere added a third after a fine turn and shot before Ipswich's Jonathan Walters netted from the penalty spot after he was fouled by Johnson.
Middlesbrough manager Gareth Southgate:
"I thought we were laboured at times, particularly in the second half when they had so much of the ball.
"The quality of the goals was excellent and I was delighted that Jeremie came off the bench and made an impact, it's nice for a manger when a player makes his point like that.
"But the game wasn't as easy for us as the score- line suggests. We were made to work hard and we lost concentration at the end and gave away a soft penalty and the clean sheet. We need to be more ruthless."
Ipswich manager Roy Keane:
"When you look at the goals we've conceded all season, it has been a horror show and there have been another three today.
"We have had decent possession and always looked a threat but as soon as we lose it we are in trouble and we've conceded a goal.
"I wouldn't call it a crisis. Supporters may call it that but I would call it a challenge. We are certainly not panicking."
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