Luton fans called for the club's board to resign after Ipswich won at Kenilworth Road to plunge the Hatters deep into relegation trouble.
Chairman Bill Tomlins was under fire after boss Mike Newell was sacked.
And Ipswich piled on the agony, going ahead six minutes before half-time when Alan Lee headed in after Alex Bruce volleyed against the bar.
Matt Richards increased the home fans' fury after 62 minutes when he turned in Fabian Wilnis' right-wing cross.
Luton Town caretaker-manager Brian Stein on demands for the club's board to resign:
"We have always been a selling club. The club is losing £2m per year.
"They get a perception that we are one of the big boys, but we are not. We get gates of 6,000 or 7,000.
"We are expected to compete with clubs like Derby, Wolves, Sheffield Wednesday and Sunderland, but we can't.
"We are Luton Town. We can't spend £2m or £3m on one player."
Ipswich Town manager Jim Magilton:
"It was pretty lively, but the importance of the three points overrode everything else for us.
"It was a gritty performance, and we got our just rewards."
Luton: Beresford, Keane, Carlisle, Heikkinen, Emanuel (Coyne 46), Foley (Runstrom 79), Barnett, Robinson, Bell, Talbot, Idrizaj (Feeney 46).
Subs Not Used: Brill, O'Leary.
Booked: Robinson, Barnett.
Ipswich: Price, Wilnis, De Vos, Bruce, Garvan, Walters (Clarke 86), Legwinski (Richards 27), Wright, Williams, Lee (Haynes 74), Roberts.
Subs Not Used: Supple, O'Callaghan.
Goals: Lee 39, Richards 62.
Ref: A D'Urso (Essex).