Cureton's goals take his season tally to 17
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Jamie Cureton grabbed a fine double to earn Colchester victory over fellow promotion-hopefuls Southampton.
Cureton fired the U's ahead on four minutes after some neat build-up play from Kem Izzet and Chris Iwelumo.
Saints responded and Danny Guthrie went close with a dipping 45-yard shot and Gareth Bale hit the post with a header.
The pressure told when Marek Saganowski shot in after a fine Andrew Surman run, but Cureton's stunning volley from Richard Garcia's cross won the points.
Southampton: Bialkowski, Baird (Viafara 46), Pele, Lundekvam, Bale, Dyer (Best 73), Guthrie, Wright, Surman, Saganowski (Rasiak 60), Wright-Phillips.
Subs Not Used: Kevin Miller, Makin.
Booked: Lundekvam, Viafara.
Goals: Saganowski 26. Colchester: Gerken, White (Mills 76), Brown, Baldwin, Barker, Garcia, Izzet, Watson, Jackson, Cureton (Guy 90), Iwelumo.
Subs Not Used: Davison, Elokobi, Ephraim.
Booked: Jackson.
Goals: Cureton 4, 27.
Att: 18,736.
Ref: T M Kettle (Rutland).