Striker Carl Cort had the home team's best chance but he prodded a volley wide after a mistake by defender Michael Duberry.
Stoke were disciplined and came close when a Clint Hill header was pushed on to the bar by keeper Stefan Postma.
A Lee Naylor cross also came back off the woodwork for Wolves but both sides struggled to create clear openings.
Wolves manager Glenn Hoddle:
"We didn't deserve more than a point.
"It's disappointing in a sense that it was a chance to gain some points.
"It would have been a nice advantage for us to get the three points but quite frankly we didn't deserve it."
Stoke assistant manager Jan de Koning:
"It was a good point for us because Wolves is always a difficult game to play away.
"At home they murdered us, but defensively we did well here and maybe that was because we played a little bit differently this time.
"We played 4-3-3 and we sat back deeper than we usually do and that made it difficult for them to score a goal."
Wolves: Postma, Ross, Lescott, Edwards, Naylor, Anderton (Ince 12), Rosa (Ricketts 64), Kennedy, Miller, Aliadiere, Cort (Frankowski 73).
Subs Not Used: Oakes, Gyepes.
Stoke: Simonsen, Hoefkens, Duberry, Hill, Broomes, Skoko (Mbuyi 82), Brammer, Gallagher, Chadwick (Sidibe 45), Russell, Bangoura.
Subs Not Used: de Goey, Sweeney, Buxton.
Ref: B Curson (Leicestershire).