Stoke missed the chance to take three points against the Owls when Kevin Harper blazed a late penalty over.
John Hills fouled Carl Hoefkens in the box, but substitute Harper was unable to convert the resulting spot-kick.
The Potters, fielding six new faces, worked hard to stay in the game after veteran Gerry Taggart was sent off for a foul on Leon Best after 13 minutes.
Wednesday did not take advantage of the extra man and when Lee Peacock did head home he was called back for offside.
Stoke assistant manager Jan de Koning:
"Our director of football John Rudge is watching the video and he might appeal.
"In my opinion it was not a sending off. It was a late tackle and he was too late for the ball.
"I thought it was a yellow card. He wanted to get the ball but the player just chipped the ball away."
Sheffield Wednesday manager Paul Sturrock:
"I think I'll have an ulcer by Christmas. There was a naivety out there. We're a very young side and we're going to have to learn quickly.
"There were spells in the game where we looked okay but you're talking about 18 19 and 20-year-old lads trying to perform at that kind of standard.
"We got a little culture shock with the pace of this league. The tempo was difficult for us to handle."
Stoke: Simonsen, Halls, Taggart, Hoefkens, Broomes, Chadwick, Junior (Henry 90), Brammer, Kolar (Harper 72), Russell (Buxton 14), Sidibe.
Subs Not Used: de Goey, Dyer.
Sent Off: Taggart (13).
Sheff Wed: Lucas, Simek, Wood, Lee, Hills, Eagles (Partridge 78), Rocastle, Whelan, Brunt, Best (Proudlock 73), Peacock.
Subs Not Used: Adams, Heckingbottom, O'Brien.
Booked: Simek, Lee, Rocastle.
Ref: M Clattenburg (Co Durham).