Oxford condemned Ebbsfleet to their fifth consecutive defeat as they cruised to a comprehensive victory.
Lewis Haldane opened the scoring when he volleyed in and James Constable then doubled the lead with a 20-yard shot.
Yemi Odubade made it 3-0 with a precise finish, before Stacy Long pulled a goal back for Ebbsfleet with a free-kick.
But the hosts' domination was never in doubt and Phil Trainer converted James Clarke's cross and Alex Fisher slotted home from close range to seal the win.
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