Jack Midson's last-gasp goal denied 10-man Lewes their first win of the season as Histon earned a point.
Lewes took a second-minute lead when Sam Gargan picked up the ball 25 yards out and smashed a shot into the net.
Rikki Banks produced a fantastic save to deny Damien Reeves' effort and also keep out Matt Langston's header after the restart as Histon poured forward.
Danny Cullip was sent off for a second booking, before Midson headed in Gareth Gwillim's last-gasp cross to level.
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