One goal from Ollie Barnes and a brace from Marvin Brown gave Salisbury a comfortable win over Oxford.
Salisbury went ahead on the half hour when Jonathan Bass crossed for Barnes to control and finish.
Brown then found the space just before half-time to strike the ball into the top corner for 2-0.
Oxford pulled one back when Yemi Odubade converted Adam Murray's corner. with 12 minutes to go before Brown made the points safe.
Salisbury: Ryan Clarke, Bass, Barnes, Asasu-Adjaye, Robinson, Turk, Darrell Clarke (Feeney 67), Fowler, Sandell, Brown, Tubbs (Matthews 77).
Subs Not Used: Bittner, Richards, Clay.
Booked: Tubbs, Asasu-Adjaye.
Goals: Barnes 31, Brown 43, 79.
Oxford Utd: Turley, Clarke, Corcoran, Foster, Jeannin (Weedon 46), Pettefer, Murray, Quinn, Trainer (Fisher 46), Odubade, Duffy (Hutchinson 53).
Subs Not Used: Warrell, Ledgister.
Booked: Corcoran, Murray, Duffy, Clarke, Odubade.
Goals: Odubade 78.
Ref: R Whitton (Essex).