Erkan Okay made one goal and scored another as Histon saw off 10-man Kidderminster Harriers.
Cliff Akurang put Histon ahead, tapping in Okay's cross before the visitors had Mark Creighton sent off after half-time for scything down Daniel Wright.
Histon made it 2-0 when Okay headed in Nathaniel Knight-Percival's centre and away keeper Chris Mackenzie made some superb stops to maintain that score.
Harriers pulled one back in injury-time when Matthew Barnes-Homer fired in.
Histon: Naisbitt, Pope, Langston, Ada, Gwillim, Okay, Cambridge, John Kennedy, Knight-Percival, Murray, Akurang (Wright 49).
Subs Not Used: Osborn, Neil Kennedy, Barker, Hipperson.
Goals: Akurang 28, Okay 54.
Kidderminster: MacKenzie, Bignot (Ferrell 71), Whitehead, Creighton, Harkness, Penn, Bennett (McGrath 85), Hurren, Blackwood, Constable (Barnes-Homer 46), Richards.
Subs Not Used: Coleman, Smikle.
Sent Off: Creighton (51).
Goals: Barnes-Homer 90.
Ref: R Whitton (Essex).