Dagenham and Redbridge struck twice after the break to see off the threat of Cambridge at Victoria Road.
The Daggers almost took the lead before the break when Sam Saunders' 18-yard cross-shot thumped against the post.
They did go ahead when Saunders' left-wing corner was headed home by Paul Benson, before Sam Sloma coolly slotted in to double their advantage.
Marcus Richardson had a header saved for Cambridge and Tommy Jaszczun was sent off for violent conduct late on.
Dag & Red: Roberts, Foster , Leberl, Uddin, Griffiths, Saunders, Southam, Rainford, Sam Sloma, Mackail-Smith, Benson.
Subs Not Used: Hogan, Batt, Lettejallow, Olayle, Weatherstone.
Goals: Benson 64, Sam Sloma 68.
Cambridge Utd: Crichton, Davies (Brady 72), Bloomer, Morrison, Jaszczun, Smith, Quinton, Josh Simpson, Marum (Pitt 76), Richardson, Gash.
Subs Not Used: Herbert, Wolleaston, Collins.
Sent Off: Jaszczun (84).
Booked: Davies, Brady.
Ref: L Hodgson (Nuneaton).
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