Southport picked up a vital point which moved them up one place in their battle to avoid relegation.
They started brightly, with Steve Daly volleying an early chance wide, but Nigel Clough's side soon took control.
Sandgrounders keeper Steven Dickinson tipped a Gary Rowett header around the post and then denied Keith Gilroy as his low drive looked destined to go in.
Aaron Webster also came close to a winner for the hosts, but he could not keep his header down from 12 yards.
Burton Albion: Deeney, Corbett, Tinson, Rowett, Webster, Shaw (Moore 84), Stride, Ducros, Gilroy (Austin 73), Harrad (Kris Taylor 68), Clare.
Subs Not Used: Henshaw, Brayford.
Southport: Dickinson, Davis, Brabin, Roberts, Lane, Pickford, Morley, Price (Blakeman 84), Fitzgerald, Robinson (Booth 65), Daly.
Subs Not Used: Jackson, Speare, Powell.
Ref: P Gibbs (West Midlands).