Cambridge brought Accrington's impressive run to a shuddering halt with a fine win at the Abbey Stadium.
Mark Angel drilled home from close range to give Cambridge a good start, and Angel turned provider with a cross for Darren Quinton to score.
Darren Bridges put the game out of Accrington's reach on the stroke of half time with a crisp volley after good work by Fola Onibuje.
Substitute Andrew Mangan curled home a right-foot shot for a late consolation.
Cambridge Utd: Behcet, Gleeson, Harkness, Duncan (Davies 73), Peters, Quinton, Smith, Bridges, Angel, Onibuje (Duffy 65), Turner (Nolan 77).
Subs Not Used: Okai, Daniels.
Goals: Angel 17, Quinton 34, Bridges 45.
Accrington Stanley: Bossu, Cavanagh (Jagielka 87), Williams, Welch, Richardson, Proctor (Mangan 45), Craney, Roberts (O'Neill 45), Barry, Mullin, Brown.
Subs Not Used: Howarth, Flynn.
Booked: Williams, Welch, Craney.
Goals: Mangan 83.
Ref: D Cann (Norfolk).