Goals from Kris Taylor, Craig Dudley and Jon Shaw sealed an emphatic victory for Nigel Clough's Burton.
Taylor gave Albion the lead after 19 minutes when he latched onto Aaron Webster's cross to fire home.
Four minutes after the interval the hosts forged further ahead when Tamika Mkandawire handled in the area and Dudley made no mistake from the spot.
When Tony James brought down Dudley with 15 minutes left, Shaw converted the penalty to seal the points.
Burton Albion: Crane, Corbett, Miller, Austin, Webster,Dudley (Ducros 83), Stride, Kris Taylor, Hall (Simpkins 74),Robins, Shaw.Subs Not Used: Kirkwood, Shilton, Robinson.
Goals: Kris Taylor 19, Dudley 49 pen, Shaw 73 pen.
Hereford: Mawson, Travis, James, Mkandawire,Robinson (Carey-Bertram 68), Green, Pitman,Hyde (Daniel Williams 45), Stanley, Stansfield,Brown (Mills 46).Subs Not Used: Smith, Scott.
Ref: M Haywood (West Yorkshire).