Ghana claimed the West African bragging rights with their first win over Nigeria in 15 years, a 4-1 victory at Brentford's Griffin Park in London.
Ghana's Laryea Kingston opened the scoring with a 20-yard strike.
Laryea Kingston's 20-yarder sparked a spate of three goals in 15, with Sulley Muntari blasting the Black Stars' second into the roof of the net.
Junior Agogo converted a cross for the third, before Taiwo Taye's penalty pulled one back for the Super Eagles.
Asamoah Frimpong scored Ghana's fourth to prompt wild celebrations.
Nigeria coach Austin Eguavoen hit-out at English premier side Chelsea and absent striker Obafemi Martins in the wake of the defeat.
Mikel Jon Obi played 90 minutes against Ghana despite Chelsea boss Jose Mourinho claiming on Saturday that Mikel would be out of action with a thigh injury and unavailable for international selection.
"Do I suspect that Chelsea were not being completely straight with me? I should think so," he said.
"Everybody saw how Mikel played. He did not show any sign of injury so I am a little bit surprised that Chelsea should have said he was injured.
Newcastle United cleared Martins to play on Tuesday, but he failed to show for the match and Eguavoen said he planned to take the matter "to the highest authority".
He added: "Martins, to my great surprise, was not here. He was called up to the squad two weeks ago, and Newcastle allowed him to play.
"He is nowhere to be found. I should take it to the highest authority, because it is the highest level of indiscipline and disrespect."