Ahly midfielder Amro Samaka has failed a drugs teat and has been left out the squad for Saturday's second leg of the African Champions League.
Samaka will miss the second leg of the Champions League final
Samaka has not travelled with his team-mates to Tunisia where they are due to play CS Sfaxien at the Rades Stadium.
The Confederation of African Football has confirmed that Samaka's first test, taken after a group match with JS Kabylie, tested positive for a banned substance.
His second sample is yet to be examined but if it too proves positive, Samaka faces a one-year ban.
Samaka is joined on the sidelines by Egyptian international Mohamed Barakat, who is suffering with an injured knee once again .
Barakat managed to battle back from injury to play in the first leg against CS Sfaxien that ended in a draw two weeks ago .
Ahly are also without midfield kingpin Mohamed Shawky, who is suspended after picking up a caution for the second time in three matches in the first leg of the final.
There are also long-term injuries to Emad Al Nahhas, striker Osama Hosni and the former Anderlecht midfielder Tarek Said.
Ahly are seeking to win the Champions League for a record-equalling fifth time and become only the third club in more than 40 years to successfully defend African football's top club prize.