England's Laura Newton has flown home from the women's tour of India after an X-ray revealed a fracture in the little finger of the left hand.
Newton scored a rapid 40 in Guwahati in Sunday's match
It means the team, 2-1 down with two matches to play, will have to do without one of their regular opening batsmen for the remaining matches.
Physiotherapist Sue Hughes said: "Laura will see a specialist who will decide whether surgery is necessary."
Newton broke the finger while fielding in Sunday's defeat at Guwahati.
She said: "I'm obviously disappointed to have to leave at such a late stage in this tour.
"I'd have liked to have finished the job we started as a team, but these things happen and I have to accept that.
"This squad has a do or die attitude and I know they'll come out fighting for the remaining two games.
Head coach Richard Bates said: "It's definitely a huge blow to lose another key member of the squad.
"Laura is a prolific run-scorer for us and to lose her as well as [seam bowler] Katherine Brunt is a major loss.
"As a squad we now really need to rally round, pull together and above all be strong as a unit."