Players such as Alok Kapali and Shahriar Nafees could face a long ban
Bangladesh have threatened to ban any player joining the unsanctioned Indian Cricket League from international cricket for 10 years.
"The decision will be equally effective for contracted players or coaches," said Bangladesh Cricket Board president Major General Sina Ibn Jamali.
Thirteen Bangladesh players have agreed to join new ICL team Dhaka Warriors.
And one of them, former captain Habibul Bashar, said only "match-fixers or drug abusers" deserved such a harsh penalty.
"We signed contracts with ICL to play cricket, not to indulge in any crime," he added.
Bangladesh have struggled to establish themselves at the top level since being granted full member status by the International Cricket Council eight years ago.
Since then, they have only won one Test out of 53 since then and although they have won 37 out of 147 one-day internationals, just five of those victories came against the eight leading cricket nations.
The 'rebel' players are, however, unrepentant about their decision to accept offers from the ICL.
"Some of the players are joining the ICL because they are fed up at the way they have been treated by the board," batsman Shahriar Nafees has been quoted as saying.
National team coach Jamie Siddons, meanwhile, believes it will be "impossible" to persuade them to change their minds.
"We'll replace these guys with young players, but my biggest concern is that the ICL will come knocking again next year," the Australian said.
"We can't afford to lose that many players on a regular basis."
Seven of the 13 players have appeared for Bangladesh in recent series.
The other six include left-arm spinner Mohammad Rafique, the only Bangladesh bowler to take 100 Test wickets, who retired from the national team earlier this year.
"All I'll say is that we haven't lost one player who was in the team for the last Test," said Siddons, who will shortly begin preparing a squad for a home series against New Zealand.
"The guys who were going are gone - and the guys who are staying can get on with the job," he added.
Bangladesh players joining ICL: Habibul Bashar (38, 50 Tests, 111 ODIs), Shahriar Nafees (22, 15 Tests, 60 ODIs), Aftab Ahmed (22, 14 Tests, 80 ODIs), Nazimuddin (22, 7 Tests), Farhad Reza (22, 32 ODIs), Dhiman Ghosh (20, 14 ODIs), Alok Kapali (24, 17 Tests, 64 ODIs), Mosharraf Hossain (26, 3 ODIs), Mohammad Rafique (38, 33 Tests, 125 ODIs) Tapash Baisya (25, 21 Tests, 56 ODIs), Manjural Islam (28, 17 Tests, 34 ODIs), Mohammad Sharif (24, 10 Tests, 9 ODIs), Golam Mabud (23, 0 Tests, 0 ODIs), Mahbubul Karim (22, 0 Tests, 0 ODIs).