Yousuf, who has a Test average of 53.07, was jettisoned from the side along with Younis Khan after the duo were blamed for the infighting which undermined their disastrous tour of Australia last winter.
Resuming on 15-3, Pakistan got off to a surprisingly comfortable start as England bowled too many balls which did not require the batsmen to play a shot.
Anderson took time to find a threatening line from around the wicket but once he did, he was back to his deadly best.
After beating Farhat with a ball that straightened slightly off the seam, he delivered a vicious inswinger which took the edge and was comfortably caught by England Test captain Andrew Strauss.
Man-of-the-match Anderson, continuing to revel in conditions tailor-made for his brand of bowling, removed Umar Akmal with another inswinger before Steven Finn snared nightwatchman Aamer, who drove uppishly and steered a thick outside edge to Kevin Pietersen in the gully.
Finn then dismissed Kamran Akmal lbw with a ball that was probably missing leg stump, the batsman unable to review the decision because Pakistan had already used up their two referrals.
Umar Gul failed to repeat his first innings heroics, although it took a spectacular catch from Paul Collingwood to dismiss him, the Durham all-rounder leaping to claim the ball with both hands as it flew above his head.
Collingwood was on hand again to snaffle an edge from Shoaib Malik to give Anderson his second five-wicket haul of the match.
And after a rapid 16 not out from Danish Kaneria, Anderson wrapped things up when Mohammad Asif nicked one to Graeme Swann in the slips.
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