It ended a dreadful series for Pietersen - though Strauss, Jonathan Trott and Matt Prior have fared equally poorly with the bat - the wicket coming about as the batsman desperately went in search of a pressure-relieving boundary.
At the other end Collingwood opted to attack, smashing Morkel over the slip cordon for two boundaries and alternating pulls with drives when facing Dale Steyn.
Smith only gave Morkel a brief rest before the tall paceman changed ends and quickly removed Ian Bell - whose weakness for fending at short-pitched balls outside off-stump was exposed when a nick flew to Jacques Kallis in the slips at head height.
Prior must have reckoned he could size up Morkel from the pavilion, electing for an ambitious pull to only his second ball and top-edging a simple catch, before Stuart Broad gloved one down the leg-side.
Graeme Swann clattered three boundaries but eventually got a nasty ball from Steyn, and the edge was again greedily snaffled in the South African slip cordon.
Debutant Wayne Parnell (left) triggered the clatter of wickets on Sunday
Collingwood, England's best batsman of the series, hit Steyn for one memorable straight six but then swept JP Duminy's first ball, a horrible long-hop, down the throat of deep backward square-leg.
The match ended in the final over of the session when Ryan Sidebottom missed a sweep against Duminy, and was bowled.
The result was a vital one for South Africa, who had lost their last home Test series and had shuffled their bowling attack several times as they tried to find a formula to defeat England.
On a wicket that was always billed as the most bowler-friendly one of the series, they were nevertheless able to declare their first innings on 423-7.
Performance to blame not reviews - Strauss
And, although England were the victims of two controversial incidents that reflected badly on the new umpire decision review system, they were thoroughly outplayed by the hosts.
England's next assignment is a tour of Bangladesh, which may be more taxing than it sounds given that some players are expected to be rested and with a number of them not in the best of form.
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