One-day international, Rose Bowl: Pakistan 273-8 beat England 271-9 by two wickets
Younis' only previous ton in ODIs had come against Hong Kong
Younis Khan hit his first one-day century against a Test-playing nation to help Pakistan beat England in the Rose Bowl day-night international.
Needing 272 to win, Pakistan won by two wickets with six balls left. Younis starred before Inzamam-ul-Haq got his team home after others had panicked.
For England, Paul Collingwood (61) and Jamie Dalrymple (62) put on 101.
At one stage, Pakistan were cruising to victory but some late wickets kept the fans interested up until the end.
Controversy again threatened to rear its head after the match when the umpires asked to see television footage of Shoaib Akhtar appearing to flick at the ball with his thumb halfway through the England innings.
But the International Cricket Council match referee Mike Procter later issued a statement saying there was no case to answer.
"After viewing television footage, the match umpires have decided no action should be taken against any Pakistan players," the statement read.
With so many bowlers out injured, for the most part England again found bowling at this level a very tall order indeed.
Younis (101) and Mohammad Yousuf (60), who produced some big partnerships against England in the Test matches, entered the fray with England on top.
Jon Lewis had had Shoaib Malik caught at point with an outswinger before Andrew Strauss ran out Mohammad Hafeez to leave them 29-2.
We showed fight. If we keep that going, we'll turn it around sooner or later
Younis was a little lucky to survive Lewis' appeal for lbw on 32 and had only added six runs to that score when hoisting Rikki Clarke to deep square leg, where Stuart Broad dropped the catch.
But as Strauss tried seven different bowlers in an attempt to find a breakthrough, the pair added 167 - a national record for the third wicket against England.
They were able to treat England's bowlers - seven of whom were tried out - with disdain and kept up with the required run rate without taking any risks.
Eventually, with the contest seemingly all but over, Younis drove Broad straight to long on. Even then Pakistan needed 76 at a run a ball and could coast home.
In the event, it was a different story as they contrived to lose five further wickets.
Yousuf was bowled by a Dalrymple delivery that turned, Afridi was caught behind off the otherwise wayward Sajid Mahmoood and Broad deceived Razzaq with his slower ball.
Paul Collingwood hit a well-palce 61 but struggled with the ball
When Broad took his third wicket by having Kamran Akmal caught at point he was on a hat-trick.
Rana Naved-ul-Hasan avoided that but was bowled by Lewis before Inzamam (44 not out) swatted the winning runs off Rikki Clarke.
Once again, England managed to show that beyond their three main batsmen, Pakistan's batting has its weak spots - but those three main batsmen had scored enough runs to win.
Pakistan named an unchanged side at the toss while the hosts recalled Mahmood for the injured Darren Gough.
Inzamam's decision to bowl first surprised some observers, with the thinking being that chasing a target under floodlights in England is often very difficult.
In good batting conditions, Strauss scored 50 rapidly after Marcus Trescothick had been yorked off his pads by the first ball of the match, bowled by Shoaib Akhtar.
But England then stumbled uncertainly from 79-1 to 125-4.
Strauss edged Naved to the wicket-keeper, Kevin Pietersen (20) tossed away his wicket and Ian Bell (42) edged Shoaib to backward point.
With half their overs still to be bowled, England needed to consolidate as Dalrymple and Collingwood faced Pakistan's three spinners.
Dalrymple struggled for runs initially and was lucky to survive an lbw appeal but some late blows gave England more hope for the future before he was yorked by Naved.
Collingwood was not quite able to stay until the end, but by scoring at a run a ball he had done arguably the best of England's trio of fifty-makers.
Chris Read's unbeaten 22 off 20 balls at the death to take England up to a good total, and with a more experienced bowling attack they would have had a huge chance of victory.
Naved finished with 4-57, while Shoaib, the only other Pakistan bowler to be given his full 10 overs, took 2-59.
Pakistan's ground fielding and running between the wickets were vastly inferior to England's.
But they are the side who go into Friday's match at Trent Bridge with a 2-0 series lead and just two matches remaining.