Veteran seamer Darren Gough will miss the remainder of the one-day series with Pakistan because of a shin injury.
Gough is still hoping to play in next year's World Cup
Gough returned to the international fold for the Twenty20 match and two one-day games but an MRI scan showed a bone stress reaction in his left shin.
He had rested for two weeks to settle bone bruising but has been told not to bowl for six weeks, making him a major doubt for October's Champions Trophy.
Uncapped Durham seamer Graham Onions, 23, has been brought into the squad.
Gough, 36 on 18 September, retired from Test cricket in 2003 but continued in the one-day arena.
He opted out of the winter tour to Pakistan but hoped to return for the India leg.
I've had a niggle for about a month, which has returned to the point where I can't go any further
Not only was he left out of that, he was also ignored for the home one-day series against Sri Lanka, in which England were whitewashed 5-0.
His return in the Twenty20 clash against Pakistan marked the end of a 13-month spell in the international wilderness, but he took 0-28 from four overs in the abandoned opening one-day game and 0-44 off eight in the second.
The Essex paceman lamented: "I was looking forward to a strong series which could have helped my chances for the upcoming winter tours.
Onions has proved expensive in limited-overs games for Durham
"I've had a niggle for about a month, which seemed to clear up with a couple of weeks rest before the series, but unfortunately it has returned to the point where I can't go any further at the moment.
"I was pleased with the way I bowled without much luck during the first few matches so it's disappointing I won't be able to play any further part in this series."
Onions, named in England's provisional 30-man squad for the Champions Trophy, has attracted the selectors' attention despite proving expensive in limited-overs cricket for his county.
He has been far more successful in four-day matches, taking 47 wickets at an average of 29.29.
Durham coach Martyn Moxon said: "He's got good pace, he's got a good seam position and he moves the ball both ways.
"We've not played him much in one-day cricket this year, but he's bowled well for us in the Championship."