England captain Michael Vaughan looks certain to miss the remainder of the current tour to India.
Vaughan and Jones both flew home from India on Tuesday
He returned home earlier this week because of a recurrence of a right knee injury and was given an injection during a visit to a Sheffield hospital.
Vaughan has been told to rest for two weeks, putting him out of the rest of the Test series against India.
And an ECB statement said it was "not anticipated" he would be fit to play in the one-day games which follow.
Andrew Flintoff has taken over as skipper in India, with regular vice-captain Marcus Trescothick having also flown home for family reasons.
Vaughan and team-mate Simon Jones, who twisted his left knee while practising for the first Test in Nagpur, were both seen by knee specialist Derk Bickerstaff on Wednesday.
Bickerstaff has worked with both players before, having performed surgery on Vaughan's knee last year and helped Jones after a horrendous right knee injury in Australia in 2002.
1999 Misses 3rd Test in South Africa with finger injury
2000 Misses home series against Zimbabwe with broken finger
2000 Strains calf muscle during tour to Pakistan
2001 Misses home Ashes series after surgery on left knee
2004 Misses first Test against New Zealand after twisting left knee
2005 Twists right knee while running between wickets in Pakistan and misses opening Test
2006 Flies home from tour to India after recurrence of knee trouble
Of Vaughan's latest injury, Bickerstaff said: "It is always the type of problem which can flare up. It is disappointing it has flared up again but some of the features are a bit different.
"Unfortunately, it is an area which does not heal itself so it is more of an issue of managing the problem."
Following his enforced rest, Vaughan will begin another period of rehabilitation under the supervision of the Yorkshire CCC physio.
Bickerstaff, meanwhile, believes Jones's problem is minor in comparison to his last knee injury.
"The potential is that he has a simple cartilage tear in his knee," he added.
"The injury he had before was a severe injury and he did well to get back to the level he is now playing.
"If there is no good evidence of a tear we would treat him conservatively and could be looking at a return in six or eight weeks."
A formal statement about Jones's condition is expected in due course.