Third one-day international, Karachi: Pakistan 353-6 (50 overs) beat England 188 all out (42 overs) by 165 runs
England equalled their heaviest defeat ever with a 165-run loss in the third one-day game as Pakistan's Kamran Akmal hit his second successive century.
Put in to bat, the hosts reached 353-6, the most ever conceded by England, with Akmal hitting 109 and Abdul Razzaq 50.
Shahid Afridi blasted 31 from 14 balls and Inzamam-ul-Haq 45 from 35.
England never looked like matching the total and were bowled out for 188 in 42 overs, with Shoaib Malik taking 3-29 and Ian Bell the top scorer with 37.
England's last defeat by such a margin was at the hands of West Indies in 1994.
HEAVIEST ENGLAND DEFEATS
165 runs v West Indies, St Vincent 1994
165 runs v Pakistan, Karachi 2005/06
162 runs v Australia, Melbourne 1999
155 runs v New Zealand, Wellington 2001/02
135 runs v West Indies, Barbados 1986
10 wkts v Sri Lanka, Colombo 2000/01
10 wkts v Australia, Sydney 2002/03
10 wkts v Sri Lanka, Dambulla 2003/04
The result in Karachi leaves them 2-1 down in the series with two to play.
Lost amid the chaos was Mohammad Yousuf's patient 68 in a stand of 104 with Akmal for Pakistan's third wicket.
England never found the same kind of platform, with the Pakistan opening bowlers finding swing that had eluded the tourists for much of their innings.
Three of the top four batsmen were out playing shots away from their bodies, with Andrew Strauss the only one to stick around.
Rana Naved outshone his partner Shoaib Akhtar, dismissing Marcus Trescothick and Vikram Solanki in the space of three balls.
Strauss was trapped lbw on the back foot by an inswinging yorker from first-change bowler Mohammad Sami.
Andrew Flintoff took his time to settle but took a liking to super-sub Yasir Arafat with three boundaries off a single over.
Shoaib was celebrating after Pakistan struck early
The pace bowler, in his first international appearance for four-and-a-half years, got his revenge, though by yorking England's star all-rounder for 36.
With his 20 overs of power play regulations over, captain Inzamam brought on his spinners, who prospered as the required run rate drifted above 10 per over.
Afridi, returning to the side after a three-match ban for damaging the pitch in the second Test, accounted for Geraint Jones and Ian Blackwell off ambitious shots.
If captain Marcus Trescothick put the home side in to bat hoping to make the most of the super-sub rule, his idea was ill conceived.
Bell was only brought in at 140-7 in the 31st over, with the match lost.
England's previous highest total conceded was India's 326-8 in the NatWest Series final at Lord's in 2002.
Trescothick made it clear at the toss he was hoping to exploit early moisture in the pitch.
There was certainly some movement early on, but James Anderson in particular struggled to control it, conceding three wides in his first six overs.
Pakistan openers Akmal and Salman Butt knew that if they saw out the early swing, the runs would come, and they did in a stand of 74.
Liam Plunkett struck twice in three balls, dismissing Butt and Younis Khan off aggressive shots.
But Yousuf and Akmal kept Pakistan at a high pace through the middle of the innings, with Steve Harmison heavily punished, his eight overs in all costing 62.
Akmal survived a single chance, on 69, when Paul Collingwood put down a return chance to his right.
Afridi was unlucky to be run out after crashing four fours and two sixes from successive overs.
And Yousuf followed in similar fashion, point fielder Paul Collingwood's second victim.
But that only increased England's pain as Razzaq hit three fours and a six off Plunkett from the first over he faced.
Razzaq and Inzamam shared a stand of 78 in seven overs of pandemonium, the worst of which saw Anderson taken for three sixes in an over costing 23 in all.