England's Simon Jones will miss the final Ashes Test after failing a fitness check on an injured right ankle which had developed a bony growth.
Jones is a key component of England's bowling attack
Jones, who has taken 18 wickets in the series, will be replaced by either James Anderson or Paul Collingwood.
The Glamorgan paceman told BBC Radio Five Live: "I did some running on Monday and it felt a little sore.
"I did some more this morning and it was no better. I am obviously gutted. It would have been nice to play."
Jones had spent much of the week in a hyperbaric oxygen chamber attempting to get fit at a London hospital.
And he had also made two trips to to the hydrotherapy unit at Arsenal's London Colney training ground - but it was all in vain.
The injury developed during England's win in the Trent Bridge Test, which England won last week to take a 2-1 lead in the series.
Jones, who had taken 5-44 in the first innings, only managed four overs with the new ball in the second before limping off.
The 26-year-old said: "I've had a few injuries in my career and you get over the disappointment.
"You have to realise these things are going to happen and be tough mentally.
"I'm going to have a chat with the medical staff and see what I can do over the next couple of weeks to ease this injury."
One option would be immediate surgery and he may then be fit for at least part of the Pakistan tour in November and December.
ECB medical officer Dr Peter Gregory hopes, however, that this will not be necessary.
"No decision will be made on Simon's availability for the tour of Pakistan until we have had an opportunity to assess how the injury responds to a period of rest.
"Surgery is an option, but the advice we have received from two leading specialists in the field is that the injury may still settle down without recourse to an operation," he said.
Jones had taken his wickets in the series at a cost of just 21 each, giving him the best average of any England bowler.
His absence is a major blow for captain Michael Vaughan, who had hoped to use the same starting XI for every one of the five Tests in the series.
As he admitted when interviewed, Jones is no stranger to injury. He hurt his back on his Test debut in 2002 and a few months later tore cruciate ligaments in his knee.
That left him out of the game for 15 months.
But he was also keen to look on the positives. "It's been the best series I've ever played in," he said.
"We're playing the best team in the world and the boys will show what they can do and hopefully bring the Ashes home.
"I'm going to go home and chill a little bit and then come back later in the week to support them."
England vice-captain Marcus Trescothick insisted the team would not be too adversely affected by the absence of the Glamorgan paceman.
"Obviously it's a setback because he's been such a good performer for us," he said. "The last few weeks is the best I've seen him bowl, but we have to move on.
"We've had a squad of about 15 for a year and a half so it won't be a new experience for whoever comes in."
As to whether it is Collingwood or Anderson that plays at The Oval, Trescothick said: "I can't really answer that, but I will give my opinion to the captain and the coach if they ask me."
Jones said his injury may have developed as a result of the way he drags his back foot when arriving at the crease to bowl.
He said: "There are a couple of bone spurs which are very uncomfortable and cause inflammation in the joint."