Dublin-born batsman Ed Joyce has been named in the England squad for Tuesday's one-day international against his native country at Stormont.
Ed Joyce helped Ireland qualify for next year's World Cup
Five uncapped players have been called up - Joyce, Tim Bresnan, Glen Chapple, Jamie Dalrymple and Alex Loudon.
However, Andrew Flintoff has been ruled out by injury so Andrew Strauss will lead England in Belfast and in the one-day games against Sri Lanka.
Michael Vaughan remains out as he continues his battle back to fitness.
Steve Harmison is back after his shin problem but Simon Jones, Ashley Giles and James Anderson remain sidelined.
The squad bears little resemblance to that hammered 5-1 in the one-day series in India earlier this year.
Kabir Ali, Gareth Batty, Matthew Hoggard, Matt Prior, Owais Shah and Vikram Solanki are all dropped, while James Anderson and Ian Blackwell are also injured.
Chairman of Selectors David Graveney said: "We do not want to take any unnecessary risks with Michael Vaughan and will wait until he is fully match-fit before considering him for selection.
This will be an exciting opportunity for the new players in the squad to make an impression
"This will be a tough test for the team. Our first-choice captain is injured, his nominated replacement Andrew Flintoff is also unavailable, as are a number of senior players.
"Andrew Strauss did an excellent job captaining the team in difficult circumstances in India, securing our only win in the series and will bring his experience of leading Middlesex to the role."
Irish-born Middlesex player Joyce qualified for England at the end of last season after helping Ireland qualify for next year's World Cup earlier in the season.
"There are significant changes in personnel from the one-day squad which toured India and this will be an exciting opportunity for the new players in the squad to make an impression," Graveney explained.
"All the uncapped players have performed well for their counties this season and will bring different qualities to the squad.
"The selections of Tim Bresnan and Glen Chapple in particular are designed to provide the captain and coach with more flexibility in the bowling attack both at the beginning and the end of an innings."
England face Ireland on Tuesday, Sri Lanka in a Twenty20 game on Thursday at the Rose Bowl, before next Saturday's first one-dayer at Lord's.
England squad: Andrew Strauss (Middlesex, captain), Ian Bell (Warwickshire), Tim Bresnan (Yorkshire), Glen Chapple (Lancashire), Paul Collingwood (Durham), Alastair Cook (Essex), James Dalrymple (Middlesex), Stephen Harmison (Durham), Geraint Jones (Kent), Ed Joyce (Middlesex), Alex Loudon (Warwickshire), Sajid Mahmood (Lancashire), Kevin Pietersen (Hampshire), Liam Plunkett (Durham), Marcus Trescothick (Somerset).