Steve Harmison has been ruled out of Durham's Friends Provident Trophy final against Hampshire on Saturday.
Harmison had recently returned after hernia surgery
The 28-year-old suffered a side injury during the Championship game against Surrey and scans confirmed he will miss his county's first ever Lord's final.
"The severity of the injury has surprised everyone and the timing couldn't be worse," Harmison said.
"Having played for Durham through the lean years I was looking forward to making my mark and I'm heartbroken."
England paceman Harmison only recently returned to action from hernia surgery, which sidelined him for the Test series against India.
Two scans identified internal bleeding in his back which appears to be related to a muscle tear and the England medical team will re-assess him to determine how long he will be out for.
The tall seamer has retired from one-day international cricket and his next potential England engagement is the first Test in Sri Lanka starting on 1 December in Kandy.
Durham coach Geoff Cook said: "Everyone is devastated for Stephen. He has worked so hard to come back from his operation and was looking forward to playing at Lord's.
"This is a cruel blow for him but when one door closes another one opens and this is a real opportunity for another one of our talented squad."
And Harnmison added: "We have a strong squad and whoever steps up to take my place will be a quality player.
"It doesn't matter which 11 players we put out at Lord's we have a good chance of bringing the trophy back to Durham and I'll be in London with the team to give them any help they need."